STAGE ISSS: Manolis Kellis

Join us for the next instalment of the STAGE International Speaker Seminar Series (ISSS) with

Dr. Manolis Kellis

Professor, MIT Computer Science and Artificial Intelligence Lab
Member, Broad Institute of MIT and Harvard
Director, MIT Computational Biology Group

Free Hybrid (In person/Online) Event | Registration Required

Talk Title:

See below.

Speaker Profile:

Manolis Kellis is a professor of computer science at MIT, a member of the Broad Institute of MIT and Harvard, a principal investigator of the Computer Science and Artificial Intelligence Lab at MIT, and head of the MIT Computational Biology Group. His research includes disease circuitry, genetics, genomics, epigenomics, coding genes, non-coding RNAs, regulatory genomics, and comparative genomics, applied to Alzheimer’s Disease, Obesity, Schizophrenia, Cardiac Disorders, Cancer, and Immune Disorders, and multiple other disorders. He has led several large-scale genomics projects, including the Roadmap Epigenomics project, the ENCODE project, the Genotype Tissue-Expression (GTEx) project, and comparative genomics projects in mammals, flies, and yeasts. He received the US Presidential Early Career Award in Science and Engineering (PECASE) by US President Barack Obama, the Mendel Medal for Outstanding Achievements in Science, the NIH Director’s Transformative Research Award, the Boston Patent Law Association award, the NSF CAREER award, the Alfred P. Sloan Fellowship, the Technology Review TR35 recognition, the AIT Niki Award, and the Sprowls award for the best Ph.D. thesis in computer science at MIT. He has authored over 245 journal publications cited more than 125,000 times. He has obtained more than 20 multi-year grants from the NIH, and his trainees hold faculty positions at Stanford, Harvard, CMU, McGill, Johns Hopkins, UCLA, and other top universities. He lived in Greece and France before moving to the US, and he studied and conducted research at MIT, the Xerox Palo Alto Research Center, and the Cold Spring Harbor Lab. His current research interests are in the area of computational biology, genomics, epigenomics, gene regulation, and genome evolution. His research group seeks to understand the mechanistic basis of human disease, using a combination of computational and experimental techniques. This involves developing methods for:

1. The systematic discovery and characterization of gene-regulatory circuits in the human genome using deep learning, graph and network analysis, dimensionality reduction, and matrix factorization techniques.
2. The systematic analysis of single-cell multi-omics and spatial transcriptomics data across gene expression and chromatin accessibility to recognize cell types, cell states, their anatomical context, and their perturbations in disease
3. The use of geometric deep learning for functional genomics and structural modeling of proteins, chemicals, and gene networks, for systematically rewiring human cellular circuits to reverse disease phenotypes.

Sponsors

Seminars are sponsored by The Hospital for Sick Children (Genetics & Genome Biology Program), the Lunenfeld-Tanenbaum Research Institute, and the McLaughlin Centre at the University of Toronto

Seminars are sponsored by The Hospital for Sick Children (Genetics & Genome Biology Program), the Lunenfeld-Tanenbaum Research Institute, and the McLaughlin Centre at the University of Toronto..

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